Welcome to the ROADMAP Trial

RandOmised Arthroplasty infection worlDwide Multidomain Adaptive Platform trial (ROADMAP)
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A Bayesian adaptive platform comparative effectiveness trial, addressing important questions to define the optimal surgical and antibiotic management of prosthetic joint infection (PJI) in hips and knees.

prosthetic joint infection (PJI)

Information for Patients

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Couple PJI

Information for Investigators‍

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study of prosthetic joint infection (PJI)
What is PJI?

When cartilage in peoples’ joints such as knees or hips wear out, it can be very painful, as bone rubs on bone without any cushioning and have a high impact on the movement.

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PJI Treatments

An infection in prosthetic or artificial joint called a prosthetic joint infection (PJI) are usually treated with a combination of surgery and antibiotics.

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Randomised controlled trials (RCTs) are the gold-standard method for generating evidence to show benefits of new therapies or interventions.

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ROADMAP TRIAL

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About the Trial

RandOmised Arthroplasty infection worlDwide Multidomain Adaptive Platform trial (ROADMAP) Trial is an innovative trial to evaluate a range of interventions with the aim of improving outcomes for patients with prosthetic joint infections with a prime focus on adult prosthetic hip and knee joints.

The objective of ROADMAP is to identify the effect of a range of clinical interventions treatment success at 12 months after treatment has been undertaken.  The study will focus on both surgical and antibiotic treatments and involve randomisation to standard treatment practices in a systematic way to measure treatment effectiveness.

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ROADMAP TRIAL

What is PJI?

Patient Information

Who is doing the study?

The ROADMAP study is being done by Medical Specialist and researchers in the fields of Infectious disease, orthopaedics and microbiology. ROADMAP is a Global trial and will be run in Australia, New Zealand, Canada, and the United Kingdom, with the plan to expand to other regions.

The study is being co-ordinated by a team based at the Hunter Medical Research Institute at the University of Newcastle, NSW, with collaborators from the University of Western Australia, the University of Melbourne, The University of Sydney, and several universities and hospitals in other countries. The lead sponsor for the study is The University of Newcastle, NSW, Australia.

Each country conducting the study will have their own regional sponsor.  In Australia, the study is funded by the Australian National Health and Medical Research Council.

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